RAP1GDS1

Across TCGA patient cohorts, RAP1GDS1 mutation is significantly associated with the total protein of many other genes, with 39 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAP1GDS1-associated genes across cancer lineages are SF2, C-Raf, and 14-3-3_beta. Each is linked with RAP1GDS1 in more than 2 cancer types. Because this analysis shows association rather than direction, both RAP1GDS1-to-partner and partner-to-RAP1GDS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SF2 grouped by RAP1GDS1-low versus RAP1GDS1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAP1GDS1→partner) and Y-score (partner→RAP1GDS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	SF2 →	-0.116	-1.797	.002	.025	3	3
UCEC	C-Raf →	+0.154	+2.000	.001	.009	3	3
UCEC	14-3-3_beta →	-0.114	-2.295	.001	.005	3	2
UCEC	ERK2 →	+0.225	+3.700	<.001	.001	3	2
UCEC	p62 Lck ligand →	+0.397	+3.807	<.001	<.001	3	2
UCEC	Annexin_VII →	-0.102	-1.736	.033	.007	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 39 associations by consensus.

SF2 by RAP1GDS1 expression — UCEC

Explore this box plot interactively →