RAP1B

Across TCGA patient cohorts, RAP1B mutation is significantly associated with the immune_cell of many other genes, with 6 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAP1B-associated genes across cancer lineages are Endothelial cells, lymphatic Endothelial cells, and mv Endothelial cells. Each is linked with RAP1B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAP1B-to-partner and partner-to-RAP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Endothelial cells grouped by RAP1B-low versus RAP1B-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAP1B→partner) and Y-score (partner→RAP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	Endothelial cells →	-0.037	-3.161	.021	.019	3	1
UCEC	lymphatic Endothelial cells →	-0.022	-2.853	.025	.002	3	1
UCEC	mv Endothelial cells →	-0.021	-3.169	.036	.019	3	1
UCEC	Myocytes →	+0.029	+2.883	.032	.032	3	1
UCEC	Plasma cells →	-0.024	-3.957	.008	<.001	3	1
UCEC	Sebocytes →	-0.026	-2.427	.014	.020	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 6 associations by consensus.

Endothelial cells by RAP1B expression — UCEC

Explore this box plot interactively →