RAP1B

Across TCGA pan-cancer cohorts, RAP1B RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated RAP1B data layer compared with 3 for mutation status and 4 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher RAP1B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RAP1B expression acts as an unfavorable survival marker, although some lineages such as KIRC and SKCM show a favorable association.

MESO, UVM, and CESC are the cancer types where RAP1B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Quartile	All	0.221	0.561	<.001	105	view →
UVM	DFS	Quartile	All	0.236	0.856	<.001	71	view →
CESC	DFS	Median	III,IV	0.207	0.677	.001	52	view →
LGG	OS	Median	All	0.742	0.881	<.001	51	view →
LIHC	OS	Median	All	0.707	0.844	<.001	40	view →
ESCA	OS	Tertile	II,III,IV	0.614	0.832	.006	35	view →
KICH	DFS	Median	II,III,IV	0.571	0.922	.004	30	view →
KIRP	OS	Median	II,III,IV	0.459	0.932	.002	30	view →
HNSC	OS	Tertile	All	0.274	0.497	.003	23	view →
ACC	DFS	Quartile	All	0.251	0.706	.003	22	view →
KIRC	DFS	Tertile	All	0.866	0.676	<.001	22	view →
SKCM	DFS	Median	All	0.247	0.159	.002	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

RAP1B–MESO (OS)

Open the MESO breakdown →