RAP1B

Across TCGA pan-cancer cohorts, RAP1B RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RAP1B’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAP1B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAP1B is over-expressed in tumor, although a few such as KICH and LUSC show the opposite, repressed pattern.

HNSC, KICH, and KIRC are the cancer types where RAP1B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAP1B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.193	<.001	12	view →
KICH	Female	All	−1.141	<.001	8	view →
KIRC	Male	All	+0.347	<.001	8	view →
LUSC	All	III,IV	−0.825	.001	6	view →
THCA	All	All	−0.233	.001	5	view →
LIHC	All	All	+0.266	.002	4	view →
CHOL	All	All	+1.444	.001	3	view →
ESCA	All	All	+1.043	<.001	2	view →
LUAD	Female	III,IV	−0.931	<.001	2	view →
READ	Female	All	−0.774	.002	2	view →
UCEC	All	All	−0.601	.001	2	view →
BLCA	Male	All	−0.413	.018	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RAP1B–HNSC

Open the HNSC breakdown →