RAP1B

Across TCGA cell cohorts, RAP1B mutation is significantly associated with the RNA expression of many other genes, with 4 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAP1B-associated genes across cancer lineages are GFRA4, ASZ1, and OR10K2. Each is linked with RAP1B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAP1B-to-partner and partner-to-RAP1B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFRA4 grouped by RAP1B-low versus RAP1B-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAP1B→partner) and Y-score (partner→RAP1B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	GFRA4 →	+0.308	+4.409	<.001	.005	3	1
BLOOD_Leukemia	ASZ1 →	+0.132	+4.152	<.001	.009	3	1
BLOOD_Leukemia	OR10K2 →	+0.060	+4.705	<.001	.003	3	1
BLOOD_Leukemia	TLE7 →	+0.032	+4.969	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 4 strongest of 4 associations by consensus.

GFRA4 by RAP1B expression — BLOOD_Leukemia

Explore this box plot interactively →