RANBP6

Across TCGA cell cohorts, RANBP6 mutation is significantly associated with the mutation status of many other genes, with 4,987 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RANBP6-associated genes across cancer lineages are EPG5, TRPC4, and PPOX. Each is linked with RANBP6 in more than 3 cancer types. Because this analysis shows association rather than direction, both RANBP6-to-partner and partner-to-RANBP6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, EPG5 grouped by RANBP6-low versus RANBP6-high in UPPER_AERODIGESTIVE_TRACT.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RANBP6→partner) and Y-score (partner→RANBP6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UPPER_AERODIGESTIVE_TRACT	EPG5 →	+4.392	+4.954	.008	.008	1	4
LARGE_INTESTINE	TRPC4 →	+1.895	+2.392	.006	.006	1	4
LARGE_INTESTINE	PPOX →	+2.409	+2.767	.001	.001	1	4
LARGE_INTESTINE	ZFAND4 →	+3.217	+3.217	<.001	<.001	1	4
LARGE_INTESTINE	CASR →	+2.310	+3.584	<.001	<.001	1	3
LARGE_INTESTINE	FAM214A →	+2.632	+2.632	.003	.003	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,987 associations by consensus.

EPG5 by RANBP6 expression — UPPER_AERODIGESTIVE_TRACT

Explore this box plot interactively →