RANBP6

Across TCGA pan-cancer cohorts, RANBP6 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of RANBP6’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where RANBP6 RNA is repressed in tumor relative to normal tissue. In most cancer types RANBP6 is over-expressed in tumor, although a few such as KIRC and THCA show the opposite, repressed pattern.

KIRC, THCA, and COAD are the cancer types where RANBP6 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RANBP6 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	III,IV	−0.708	<.001	9	view →
THCA	All	All	−0.350	<.001	7	view →
COAD	Male	All	+0.546	<.001	5	view →
CHOL	Male	All	+1.533	<.001	4	view →
LUSC	All	III,IV	−0.726	<.001	4	view →
LIHC	All	All	+0.258	.022	3	view →
KICH	All	All	−0.644	.006	2	view →
BRCA	Female	All	−0.164	.031	2	view →
READ	All	II,III,IV	+0.722	.043	1	view →
KIRP	Male	All	−0.297	.025	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

RANBP6–KIRC

Open the KIRC breakdown →