RAD54L

Across TCGA cell cohorts, RAD54L mutation is significantly associated with the mutation status of many other genes, with 1,223 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible RAD54L-associated genes across cancer lineages are SAMD4A, PTGER3, and PWWP2B. Each is linked with RAD54L in more than 2 cancer types. Because this analysis shows association rather than direction, both RAD54L-to-partner and partner-to-RAD54L results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SAMD4A grouped by RAD54L-low versus RAD54L-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAD54L→partner) and Y-score (partner→RAD54L) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	SAMD4A →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	PTGER3 →	+4.187	+5.000	.008	.008	1	3
LUNG_NSCLC_LUAD	PWWP2B →	+4.772	+5.339	.004	.004	1	3
LARGE_INTESTINE	ATG5 →	+3.459	+3.459	.006	.006	1	3
UPPER_AERODIGESTIVE_TRACT	PSMD5 →	+4.954	+4.392	.008	.008	1	3
BLOOD_Leukemia	PPFIBP1 →	+3.399	+3.669	<.001	<.001	1	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,223 associations by consensus.

SAMD4A by RAD54L expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →