RAD54L

Across TCGA pan-cancer cohorts, RAD54L RNA is linked to patient survival in 29 of 34 cancer types, making it the most broadly survival-associated RAD54L data layer compared with 4 for mutation status.

The strongest signal is observed in adrenocortical carcinoma (ACC), where higher RAD54L RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated RAD54L expression acts as an unfavorable survival marker, although some lineages such as UCEC and OV show a favorable association.

ACC, KIRC, and MESO are the cancer types where RAD54L RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
ACC	DFS	Median	All	0.216	0.665	<.001	156	view →
KIRC	DFS	Tertile	All	0.490	0.747	<.001	151	view →
MESO	OS	Median	All	0.379	0.699	<.001	129	view →
KIRP	DFS	Median	All	0.782	0.922	<.001	103	view →
LIHC	DFS	Median	All	0.435	0.645	<.001	100	view →
KICH	DFS	Tertile	III,IV	0.142	1.000	<.001	94	view →
PAAD	OS	Tertile	All	0.312	0.558	<.001	60	view →
LGG	DFS	Median	All	0.632	0.843	<.001	54	view →
THCA	DFS	Tertile	II,III,IV	0.717	0.900	.001	45	view →
SARC	DFS	Median	All	0.419	0.607	<.001	41	view →
SKCM	DFS	Tertile	II,III,IV	0.425	0.767	<.001	37	view →
UCEC	DFS	Tertile	IV	0.772	0.278	.006	32	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 29 lineages.

RAD54L–ACC (DFS)

Open the ACC breakdown →