RAB7A

Across TCGA cell cohorts, RAB7A RNA expression is significantly associated with the go_rna of many other GO terms, with 4,877 significant associations in total. BONE shows the largest number of these associations.

The most reproducible RAB7A-associated GO terms across cancer lineages are Regulation of early endosome to late endosome transport, Synaptic vesicle lumen acidification, and Endosomal transport. Each is linked with RAB7A in more than 15 cancer types. Because this analysis shows association rather than direction, both RAB7A-to-partner and partner-to-RAB7A results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of early endosome to late endosome transport grouped by RAB7A-low versus RAB7A-high in CNS.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB7A→partner) and Y-score (partner→RAB7A) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
CNS	Regulation of early endosome to late endosome transport →	+0.126	+0.598	<.001	<.001	3	16
SOFT_TISSUE	Synaptic vesicle lumen acidification →	+0.168	+0.780	<.001	<.001	3	13
SKIN	Endosomal transport →	+0.067	+0.791	<.001	<.001	3	12
SKIN	Endosomal vesicle fusion →	+0.105	+0.773	<.001	<.001	3	12
UPPER_AERODIGESTIVE_TRACT	Postsynapse to nucleus signaling pathway →	+0.158	+0.706	<.001	.001	3	12
LARGE_INTESTINE	Endocytic recycling →	+0.060	+0.642	<.001	<.001	3	11

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,877 associations by consensus.

Regulation of early endosome to late endosome transport by RAB7A expression — CNS

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