RAB7A

Across TCGA pan-cancer cohorts, RAB7A RNA is linked to patient survival in 24 of 34 cancer types, making it the most broadly survival-associated RAB7A data layer compared with 1 for mutation status and 5 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher RAB7A RNA is associated with better overall survival. In most high-consensus cancer types, elevated RAB7A expression acts as an unfavorable survival marker, although some lineages such as KIRC and UVM show a favorable association.

KIRC, LIHC, and PAAD are the cancer types where RAB7A RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Tertile	All	0.745	0.544	<.001	75	view →
LIHC	DFS	Tertile	All	0.440	0.635	<.001	57	view →
PAAD	OS	Median	All	0.247	0.632	<.001	55	view →
COAD	DFS	Quartile	All	0.525	0.767	.001	48	view →
UVM	OS	Median	All	0.946	0.681	.004	45	view →
THCA	OS	Median	II,III,IV	0.990	0.908	.002	30	view →
KICH	DFS	Median	II,III,IV	0.609	0.913	.015	25	view →
LUSC	DFS	Quartile	III,IV	0.165	0.804	.005	25	view →
BLCA	DFS	Tertile	II,III,IV	0.568	0.675	.009	24	view →
UCEC	OS	Median	All	0.836	0.904	.007	24	view →
ACC	DFS	Median	II,III,IV	0.204	0.632	.002	23	view →
LGG	OS	Quartile	All	0.817	0.942	.001	19	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 24 lineages.

RAB7A–KIRC (OS)

Open the KIRC breakdown →