RAB7A

Across TCGA pan-cancer cohorts, RAB7A RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of RAB7A’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAB7A RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAB7A is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, LIHC, and STAD are the cancer types where RAB7A tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB7A RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	IV	+1.042	<.001	12	view →
LIHC	All	II,III,IV	+0.573	<.001	8	view →
STAD	All	II,III,IV	+0.405	.002	7	view →
BRCA	All	III,IV	+0.363	<.001	6	view →
KICH	All	All	−0.667	<.001	5	view →
BLCA	All	All	+0.361	.009	5	view →
LUSC	Male	All	+0.465	<.001	4	view →
LUAD	All	All	−0.213	.001	4	view →
CHOL	Male	All	+1.089	<.001	3	view →
UCEC	All	All	−0.346	.032	2	view →
KIRP	All	All	+0.239	.018	2	view →
ESCA	All	All	+0.810	.018	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

RAB7A–HNSC

Open the HNSC breakdown →