RAB3IP

Across TCGA cell cohorts, RAB3IP mutation is significantly associated with the RNA expression of many other genes, with 14 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible RAB3IP-associated genes across cancer lineages are DEFB132, OR13C7, and PITX3. Each is linked with RAB3IP in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB3IP-to-partner and partner-to-RAB3IP results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, DEFB132 grouped by RAB3IP-low versus RAB3IP-high in LUNG_SCLC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB3IP→partner) and Y-score (partner→RAB3IP) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_SCLC	DEFB132 →	+0.012	+5.029	<.001	.006	3	2
BLOOD_Leukemia	OR13C7 →	+0.017	+4.969	<.001	.003	3	1
LARGE_INTESTINE	PITX3 →	+0.205	+3.643	<.001	.005	3	1
LARGE_INTESTINE	MAS1 →	+0.003	+4.022	<.001	.006	3	1
LARGE_INTESTINE	ZNF454 →	+0.248	+3.658	<.001	.005	3	1
LARGE_INTESTINE	OR4F5 →	+0.024	+3.345	<.001	.007	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 14 associations by consensus.

DEFB132 by RAB3IP expression — LUNG_SCLC

Explore this box plot interactively →