RAB36

Across TCGA patient cohorts, RAB36 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB36-associated genes across cancer lineages are JNK_pT183_Y185, MEK1, and mTOR_pS2448. Each is linked with RAB36 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB36-to-partner and partner-to-RAB36 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, JNK_pT183_Y185 grouped by RAB36-low versus RAB36-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB36→partner) and Y-score (partner→RAB36) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	JNK_pT183_Y185 →	-0.241	-2.999	.006	.035	3	1
UCEC	MEK1 →	+0.442	+3.000	.021	.036	3	1
UCEC	mTOR_pS2448 →	-0.161	-2.980	.039	.036	3	1
UCEC	VHL →	-1.012	-3.321	.004	.010	3	1
UCEC	Cyclin-E2 →	+0.254	+2.817	.004	.036	3	1
UCEC	eEF2 →	+0.649	+3.000	<.001	.036	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

JNK_pT183_Y185 by RAB36 expression — UCEC

Explore this box plot interactively →