RAB31

Across TCGA patient cohorts, RAB31 mutation is significantly associated with the total protein of many other genes, with 11 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB31-associated genes across cancer lineages are FoxM1, MEK1, and mTOR_pS2448. Each is linked with RAB31 in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB31-to-partner and partner-to-RAB31 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, FoxM1 grouped by RAB31-low versus RAB31-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB31→partner) and Y-score (partner→RAB31) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	FoxM1 →	+0.247	+2.459	.048	.020	3	1
UCEC	MEK1 →	+0.442	+3.459	.012	.005	3	1
UCEC	mTOR_pS2448 →	-0.179	-2.986	.012	.035	3	1
UCEC	PDCD4 →	-0.725	-2.999	.001	.035	3	1
UCEC	Rab25 →	-0.339	-3.321	.034	.010	3	1
UCEC	EGFR_pY1068 →	-0.304	-3.169	.012	.019	2	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 11 associations by consensus.

FoxM1 by RAB31 expression — UCEC

Explore this box plot interactively →