RAB31

Across TCGA pan-cancer cohorts, RAB31 RNA differs between tumor and matched normal tissue in 12 of 18 cancer types tested, making tumor–normal expression one of RAB31’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where RAB31 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAB31 is over-expressed in tumor, although a few such as UCEC and LUSC show the opposite, repressed pattern.

HNSC, KIRC, and BRCA are the cancer types where RAB31 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB31 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Male	III,IV	+1.835	<.001	12	view →
KIRC	Male	IV	+1.112	<.001	11	view →
BRCA	All	III,IV	+1.683	<.001	8	view →
KIRP	Male	All	+1.220	<.001	7	view →
UCEC	All	All	−2.036	<.001	6	view →
CHOL	All	All	+2.592	<.001	5	view →
LIHC	All	II,III,IV	+0.791	.002	5	view →
LUSC	All	All	−0.656	<.001	4	view →
PRAD	All	All	−0.715	<.001	2	view →
LUAD	All	All	−0.337	.006	2	view →
STAD	Male	II,III,IV	+0.909	.033	1	view →
COAD	Male	IV	+0.876	.032	1	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 12 lineages.

RAB31–HNSC

Open the HNSC breakdown →