RAB27B

Across TCGA patient cohorts, RAB27B mutation is significantly associated with the total protein of many other genes, with 18 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible RAB27B-associated genes across cancer lineages are c-Met_pY1235, Smad3, and GAPDH. Each is linked with RAB27B in more than 1 cancer types. Because this analysis shows association rather than direction, both RAB27B-to-partner and partner-to-RAB27B results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, c-Met_pY1235 grouped by RAB27B-low versus RAB27B-high in SKCM.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (RAB27B→partner) and Y-score (partner→RAB27B) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKCM	c-Met_pY1235 →	+0.091	+3.000	.015	.034	3	2
UCEC	Smad3 →	+0.163	+3.000	.039	.036	3	2
SKCM	GAPDH →	+0.608	+3.169	.020	.018	3	1
SKCM	HER3 →	+0.449	+2.321	.015	.033	3	1
SKCM	Syk →	-0.767	-2.983	<.001	.034	3	1
UCEC	JNK_pT183_Y185 →	-0.212	-3.308	.016	.010	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 18 associations by consensus.

c-Met_pY1235 by RAB27B expression — SKCM

Explore this box plot interactively →