RAB27B

Across TCGA pan-cancer cohorts, RAB27B RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of RAB27B’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where RAB27B RNA is more highly expressed in tumor relative to normal tissue. In most cancer types RAB27B is over-expressed in tumor, although a few such as COAD show the opposite, repressed pattern.

BLCA, THCA, and KIRP are the cancer types where RAB27B tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in RAB27B RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	All	+1.578	.024	7	view →
THCA	Male	All	+1.440	<.001	7	view →
KIRP	All	III,IV	+1.359	.002	7	view →
BRCA	All	II,III,IV	+0.726	.001	6	view →
KICH	All	All	+1.471	<.001	5	view →
KIRC	Male	All	+0.667	<.001	5	view →
LUAD	Female	All	+0.720	.001	3	view →
CHOL	All	All	+2.439	.001	2	view →
PAAD	All	All	+1.455	.021	2	view →
COAD	Female	All	−0.938	.010	2	view →
PRAD	All	All	+0.560	.028	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

RAB27B–BLCA

Open the BLCA breakdown →