RAB27B

Across TCGA pan-cancer cohorts, RAB27B RNA is linked to patient survival in 23 of 34 cancer types, making it the most broadly survival-associated RAB27B data layer compared with 5 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in lung adenocarcinoma (LUAD), where higher RAB27B RNA is associated with worse overall survival. In most high-consensus cancer types, elevated RAB27B expression acts as an unfavorable survival marker, although some lineages such as COAD and LGG show a favorable association.

LUAD, KIRP, and PAAD are the cancer types where RAB27B RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
LUAD	OS	Median	All	0.228	0.472	<.001	78	view →
KIRP	DFS	Median	All	0.572	0.882	.003	73	view →
PAAD	OS	Tertile	All	0.259	0.577	<.001	52	view →
UVM	DFS	Tertile	II,III,IV	0.451	0.751	.002	40	view →
COAD	DFS	Median	II,III,IV	0.736	0.542	.002	37	view →
LAML	DFS	Tertile	All	0.201	0.635	.001	36	view →
LGG	OS	Median	All	0.943	0.844	<.001	33	view →
LUSC	OS	Quartile	All	0.304	0.521	<.001	25	view →
BRCA	DFS	Median	IV	0.698	0.284	.002	22	view →
PRAD	DFS	Median	All	0.861	0.715	<.001	18	view →
HNSC	DFS	Tertile	All	0.757	0.641	.003	17	view →
DLBC	DFS	Quartile	IV	0.172	0.803	.017	13	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 23 lineages.

RAB27B–LUAD (OS)

Open the LUAD breakdown →