R3HDML

Across TCGA patient cohorts, R3HDML mutation is significantly associated with the total protein of many other genes, with 10 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible R3HDML-associated genes across cancer lineages are cIAP, JNK2, and MSH2. Each is linked with R3HDML in more than 1 cancer types. Because this analysis shows association rather than direction, both R3HDML-to-partner and partner-to-R3HDML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, cIAP grouped by R3HDML-low versus R3HDML-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HDML→partner) and Y-score (partner→R3HDML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	cIAP →	+0.150	+3.009	.030	.019	3	2
UCEC	JNK2 →	+0.281	+2.321	.004	.035	3	1
UCEC	MSH2 →	-0.437	-2.990	<.001	.036	3	1
UCEC	Notch1 →	+0.177	+3.009	.012	.019	3	1
UCEC	PDCD4 →	-0.629	-3.160	.007	.019	3	1
UCEC	4E-BP1_pT37_T46 →	-0.613	-2.321	.001	.035	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 10 associations by consensus.

cIAP by R3HDML expression — UCEC

Explore this box plot interactively →