R3HDML

Across TCGA pan-cancer cohorts, R3HDML RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated R3HDML data layer compared with 6 for mutation status and 1 for mass-spec protein.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher R3HDML RNA is associated with worse disease-free survival. In most high-consensus cancer types, elevated R3HDML expression acts as an unfavorable survival marker, although some lineages such as UCS and COAD show a favorable association.

KIRC, LUSC, and UCS are the cancer types where R3HDML RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	DFS	Tertile	All	0.462	0.681	<.001	113	view →
LUSC	OS	Quartile	II,III,IV	0.662	0.852	<.001	58	view →
UCS	DFS	Median	II,III,IV	0.458	0.156	.006	26	view →
ACC	OS	Tertile	All	0.726	0.898	.012	21	view →
BRCA	DFS	Tertile	IV	0.279	0.688	.003	18	view →
CESC	OS	Tertile	IV	0.364	0.629	.041	18	view →
THCA	OS	Quartile	III,IV	0.860	0.959	.008	16	view →
CHOL	DFS	Tertile	III,IV	0.174	0.779	.024	14	view →
SCLC	OS	Median	II,III,IV	0.501	1.000	.012	12	view →
COAD	OS	Tertile	II,III,IV	0.791	0.422	.013	12	view →
TGCT	DFS	Median	II,III,IV	0.772	1.000	.041	10	view →
KICH	DFS	Tertile	IV	0.269	0.784	.045	9	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

R3HDML–KIRC (DFS)

Open the KIRC breakdown →