R3HDML

Across TCGA pan-cancer cohorts, R3HDML RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of R3HDML’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where R3HDML RNA is repressed in tumor relative to normal tissue. In most cancer types R3HDML is over-expressed in tumor, although a few such as KIRC and KIRP show the opposite, repressed pattern.

KIRC, COAD, and STAD are the cancer types where R3HDML tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in R3HDML RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	All	All	−0.142	<.001	11	view →
COAD	All	II,III,IV	+1.118	<.001	10	view →
STAD	All	II,III,IV	+0.403	<.001	6	view →
BRCA	Female	II,III,IV	+0.117	<.001	6	view →
KIRP	All	All	−0.157	<.001	5	view →
KICH	All	All	−0.080	.002	4	view →
HNSC	All	All	+0.058	.015	3	view →
READ	Female	All	+1.742	<.001	2	view →
LUAD	Male	II,III,IV	+0.690	.007	2	view →
LIHC	Male	All	+0.122	.002	2	view →
THCA	Male	III,IV	−0.038	.019	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 11 strongest of 11 lineages.

R3HDML–KIRC

Open the KIRC breakdown →