R3HDML

Across TCGA cell cohorts, R3HDML RNA expression is significantly associated with the go_rna of many other GO terms, with 472 significant associations in total. SKIN shows the largest number of these associations.

The most reproducible R3HDML-associated GO terms across cancer lineages are Aromatic amino acid family catabolic process, Late endosome to lysosome transport, and Negative regulation of supramolecular fiber organization. Each is linked with R3HDML in more than 3 cancer types. Because this analysis shows association rather than direction, both R3HDML-to-partner and partner-to-R3HDML results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Aromatic amino acid family catabolic process grouped by R3HDML-low versus R3HDML-high in SKIN.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HDML→partner) and Y-score (partner→R3HDML) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	Aromatic amino acid family catabolic process →	-0.143	-0.016	.002	.002	3	4
STOMACH	Late endosome to lysosome transport →	+0.110	+0.034	.006	.002	3	3
STOMACH	Negative regulation of supramolecular fiber organization →	+0.076	+0.024	<.001	<.001	3	3
STOMACH	Regulation of protein localization to cell periphery →	+0.065	+0.020	.007	.005	3	3
STOMACH	Positive regulation of establishment of protein localization →	+0.042	+0.030	<.001	.007	3	3
STOMACH	Regulation of stem cell differentiation →	+0.083	+0.037	<.001	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 472 associations by consensus.

Aromatic amino acid family catabolic process by R3HDML expression — SKIN

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