R3HCC1

Across TCGA patient cohorts, R3HCC1 mutation is significantly associated with the RNA expression of many other genes, with 954 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible R3HCC1-associated genes across cancer lineages are PRSS53, BAG3, and AP1S3. Each is linked with R3HCC1 in more than 1 cancer types. Because this analysis shows association rather than direction, both R3HCC1-to-partner and partner-to-R3HCC1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PRSS53 grouped by R3HCC1-low versus R3HCC1-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (R3HCC1→partner) and Y-score (partner→R3HCC1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	PRSS53 →	+0.305	+2.297	.001	.005	3	1
UCEC	BAG3 →	+0.711	+2.523	<.001	.009	3	1
UCEC	AP1S3 →	+0.868	+2.960	<.001	<.001	3	1
UCEC	GPATCH11 →	+0.430	+3.502	.007	.002	3	1
UCEC	C18orf25 →	+0.456	+3.332	.006	.005	3	1
UCEC	USP12 →	+0.534	+2.906	.003	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 954 associations by consensus.

PRSS53 by R3HCC1 expression — UCEC

Explore this box plot interactively →