QSOX1

Across TCGA cell cohorts, QSOX1 mutation is significantly associated with the RNA expression of many other genes, with 15 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible QSOX1-associated genes across cancer lineages are PNMA3, OR6B3, and P2RY13. Each is linked with QSOX1 in more than 1 cancer types. Because this analysis shows association rather than direction, both QSOX1-to-partner and partner-to-QSOX1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, PNMA3 grouped by QSOX1-low versus QSOX1-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (QSOX1→partner) and Y-score (partner→QSOX1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	PNMA3 →	+0.124	+2.781	.005	.009	3	1
SKIN	OR6B3 →	+0.081	+4.437	<.001	.004	3	1
SKIN	P2RY13 →	+0.005	+3.684	<.001	.006	3	1
SKIN	KRTAP5-4 →	+0.067	+4.562	<.001	<.001	3	1
OVARY	OR7D4 →	+0.056	+5.196	<.001	.005	3	1
OVARY	OR10G2 →	+0.026	+5.196	<.001	.005	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 15 associations by consensus.

PNMA3 by QSOX1 expression — LARGE_INTESTINE

Explore this box plot interactively →