QSOX1

Across TCGA pan-cancer cohorts, QSOX1 RNA differs between tumor and matched normal tissue in 10 of 18 cancer types tested, making tumor–normal expression one of QSOX1’s most consistent transcriptional readouts.

The strongest signal is observed in thyroid carcinoma (THCA), where QSOX1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types QSOX1 is over-expressed in tumor, although a few such as LUSC and PRAD show the opposite, repressed pattern.

THCA, KIRC, and LUSC are the cancer types where QSOX1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in QSOX1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
THCA	Male	III,IV	+1.710	<.001	11	view →
KIRC	Male	All	+0.920	<.001	11	view →
LUSC	All	II,III,IV	−0.949	<.001	8	view →
KICH	Female	II,III,IV	+1.164	.004	6	view →
BRCA	All	All	+0.421	<.001	6	view →
HNSC	All	All	+0.497	<.001	5	view →
CHOL	All	All	+3.795	<.001	3	view →
PAAD	All	All	+1.950	.025	2	view →
PRAD	All	All	−1.031	<.001	2	view →
BLCA	All	All	−0.541	.021	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 10 strongest of 10 lineages.

QSOX1–THCA

Open the THCA breakdown →