PYGO2

Across TCGA patient cohorts, PYGO2 mutation is significantly associated with the RNA expression of many other genes, with 379 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYGO2-associated genes across cancer lineages are OR8A3P, IGLJ7, and RNU6-376P. Each is linked with PYGO2 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYGO2-to-partner and partner-to-PYGO2 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, OR8A3P grouped by PYGO2-low versus PYGO2-high in LIHC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGO2→partner) and Y-score (partner→PYGO2) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIHC	OR8A3P →	+0.153	+5.008	<.001	.004	3	2
COAD	IGLJ7 →	+1.719	+3.280	.001	.004	3	2
LUSC	RNU6-376P →	+0.236	+4.548	.002	.009	3	2
UCEC	CYP4F27P →	+0.236	+2.519	.006	<.001	3	2
UCEC	SUMO2P15 →	+0.252	+2.159	.002	.002	3	1
UCEC	RN7SKP290 →	+0.181	+2.773	.007	.004	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 379 associations by consensus.

OR8A3P by PYGO2 expression — LIHC

Explore this box plot interactively →