PYGM

Across TCGA patient cohorts, PYGM protein abundance is significantly associated with the RNA expression of many other genes, with 16,054 significant associations in total. LSCC shows the largest number of these associations.

The most reproducible PYGM-associated genes across cancer lineages are SYNPO2, MYOM1, and SGCA. Each is linked with PYGM in more than 8 cancer types. Because this analysis shows association rather than direction, both PYGM-to-partner and partner-to-PYGM results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PYGM versus SYNPO2 in HNSC, with a Pearson correlation of 0.47.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGM→partner) and Y-score (partner→PYGM) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
HNSC	SYNPO2 →	+1.730	+1.251	<.001	<.001	3	9
HNSC	MYOM1 →	+1.220	+0.974	<.001	<.001	3	8
HNSC	SGCA →	+1.171	+0.998	<.001	<.001	3	8
CCRCC	PLSCR4 →	+0.875	+0.522	<.001	<.001	3	8
CCRCC	EMCN →	+1.159	+0.464	<.001	<.001	3	8
GBM	PHYHIP →	+1.227	+0.695	<.001	<.001	3	8

Each partner links to its Q-omics profile. Showing the 6 strongest of 16,054 associations by consensus.

PYGM vs SYNPO2 — HNSC

Explore this scatter interactively →