PYGM

Across TCGA pan-cancer cohorts, PYGM RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of PYGM’s most consistent transcriptional readouts.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where PYGM RNA is repressed in tumor relative to normal tissue. In most cancer types PYGM is over-expressed in tumor, although a few such as BLCA and THCA show the opposite, repressed pattern.

BLCA, THCA, and COAD are the cancer types where PYGM tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PYGM RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
BLCA	Male	IV	−5.080	<.001	11	view →
THCA	Male	III,IV	−2.818	<.001	11	view →
COAD	Male	II,III,IV	−2.211	<.001	11	view →
LUAD	Female	III,IV	−0.984	<.001	9	view →
KIRP	Male	All	−0.964	<.001	9	view →
KICH	All	III,IV	−0.831	<.001	9	view →
HNSC	All	IV	−3.704	<.001	8	view →
UCEC	All	III,IV	−3.518	<.001	8	view →
LUSC	Female	II,III,IV	−1.212	<.001	8	view →
READ	All	All	−2.713	<.001	7	view →
STAD	All	All	−1.836	<.001	7	view →
BRCA	All	III,IV	−2.071	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

PYGM–BLCA

Open the BLCA breakdown →