PYGL

Across TCGA cell cohorts, PYGL mutation is significantly associated with the RNA expression of many other genes, with 25 significant associations in total. LUNG_NSCLC_LUAD shows the largest number of these associations.

The most reproducible PYGL-associated genes across cancer lineages are POTEB, OR10G2, and DTHD1. Each is linked with PYGL in more than 1 cancer types. Because this analysis shows association rather than direction, both PYGL-to-partner and partner-to-PYGL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, POTEB grouped by PYGL-low versus PYGL-high in LUNG_NSCLC_LUAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGL→partner) and Y-score (partner→PYGL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LUNG_NSCLC_LUAD	POTEB →	+0.006	+3.813	<.001	.001	3	2
LUNG_NSCLC_LUAD	OR10G2 →	+0.017	+3.043	<.001	.006	3	2
URINARY_TRACT	DTHD1 →	+0.056	+5.087	<.001	.004	3	1
LUNG_NSCLC_LUAD	CD2 →	+0.051	+3.321	<.001	.005	3	1
LUNG_NSCLC_LUAD	OR6C2 →	+0.256	+3.189	<.001	.007	3	1
LUNG_NSCLC_LUAD	OR2V2 →	+0.019	+3.374	<.001	.002	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 25 associations by consensus.

POTEB by PYGL expression — LUNG_NSCLC_LUAD

Explore this box plot interactively →