PYGL

Across TCGA pan-cancer cohorts, PYGL RNA differs between tumor and matched normal tissue in 11 of 18 cancer types tested, making tumor–normal expression one of PYGL’s most consistent transcriptional readouts.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where PYGL RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PYGL is over-expressed in tumor, although a few such as KICH and BRCA show the opposite, repressed pattern.

KIRC, HNSC, and BLCA are the cancer types where PYGL tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PYGL RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
KIRC	Male	All	+2.328	<.001	12	view →
HNSC	Female	III,IV	+2.219	<.001	12	view →
BLCA	All	III,IV	+1.605	.005	8	view →
KIRP	Male	All	+1.304	<.001	7	view →
KICH	Female	II,III,IV	−2.415	<.001	6	view →
LUSC	Male	II,III,IV	+1.115	<.001	6	view →
BRCA	All	All	−0.921	<.001	6	view →
UCEC	All	All	+0.855	.004	6	view →
CHOL	All	All	−2.073	.001	5	view →
PRAD	All	All	−1.000	<.001	2	view →
LUAD	All	IV	−0.804	.038	2	view →
LUAD	All	All	+0.352	.016	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 11 lineages.

PYGL–KIRC

Open the KIRC breakdown →