PYGB

Across TCGA patient cohorts, PYGB mutation is significantly associated with the RNA expression of many other genes, with 3,774 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYGB-associated genes across cancer lineages are GFI1, DHRS13, and FDFT1. Each is linked with PYGB in more than 2 cancer types. Because this analysis shows association rather than direction, both PYGB-to-partner and partner-to-PYGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GFI1 grouped by PYGB-low versus PYGB-high in COAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGB→partner) and Y-score (partner→PYGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
COAD	GFI1 →	+0.832	+3.605	.001	.001	3	3
UCEC	DHRS13 →	+0.612	+2.535	<.001	<.001	3	3
UCEC	FDFT1 →	+0.587	+2.202	<.001	<.001	3	3
UCEC	SLC17A5 →	+0.572	+3.108	<.001	<.001	3	3
UCEC	NDUFAF1 →	+0.503	+2.180	<.001	<.001	3	3
UCEC	PPP2CB →	+0.443	+1.934	.002	.002	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 3,774 associations by consensus.

GFI1 by PYGB expression — COAD

Explore this box plot interactively →