PYGB

Across TCGA patient cohorts, PYGB mutation is significantly associated with the total protein of many other genes, with 46 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYGB-associated genes across cancer lineages are GAPDH, C-Raf, and eEF2. Each is linked with PYGB in more than 2 cancer types. Because this analysis shows association rather than direction, both PYGB-to-partner and partner-to-PYGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, GAPDH grouped by PYGB-low versus PYGB-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGB→partner) and Y-score (partner→PYGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	GAPDH →	+0.437	+2.222	.016	.009	3	3
COAD	C-Raf →	+0.169	+1.882	.005	.031	3	2
UCEC	eEF2 →	+0.343	+2.222	.004	.009	3	2
UCEC	JNK_pT183_Y185 →	-0.148	-1.234	.009	.045	3	2
UCEC	NF2 →	+0.223	+1.807	.002	.024	3	2
UCEC	p21 →	+0.141	+1.750	.031	.049	3	2

Each partner links to its Q-omics profile. Showing the 6 strongest of 46 associations by consensus.

GAPDH by PYGB expression — UCEC

Explore this box plot interactively →