PYGB

Across TCGA cell cohorts, PYGB RNA expression is significantly associated with the go_rna of many other GO terms, with 4,349 significant associations in total. BONE shows the largest number of these associations.

The most reproducible PYGB-associated GO terms across cancer lineages are Actin filament depolymerization, Protein depolymerization, and Positive regulation of intracellular protein transport. Each is linked with PYGB in more than 10 cancer types. Because this analysis shows association rather than direction, both PYGB-to-partner and partner-to-PYGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Actin filament depolymerization grouped by PYGB-low versus PYGB-high in LIVER.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGB→partner) and Y-score (partner→PYGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LIVER	Actin filament depolymerization →	+0.172	+1.241	.003	.002	3	11
LUNG_NSCLC_LUSC	Protein depolymerization →	+0.152	+1.280	<.001	.007	2	11
SOFT_TISSUE	Positive regulation of intracellular protein transport →	+0.056	+0.963	<.001	<.001	3	10
BONE	Protein lipoylation →	-0.180	-1.375	<.001	<.001	3	10
BONE	Positive regulation of intracellular transport →	+0.088	+1.403	<.001	.001	3	10
BONE	Phosphatidylinositol biosynthetic process →	+0.071	+1.379	<.001	<.001	3	10

Each partner links to its Q-omics profile. Showing the 6 strongest of 4,349 associations by consensus.

Actin filament depolymerization by PYGB expression — LIVER

Explore this box plot interactively →