PYGB

Across TCGA cell cohorts, PYGB mutation is significantly associated with the RNA expression of many other genes, with 277 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PYGB-associated genes across cancer lineages are SPDYE4, DPH5, and ATG4C. Each is linked with PYGB in more than 1 cancer types. Because this analysis shows association rather than direction, both PYGB-to-partner and partner-to-PYGB results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, SPDYE4 grouped by PYGB-low versus PYGB-high in BLOOD_Leukemia.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYGB→partner) and Y-score (partner→PYGB) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BLOOD_Leukemia	SPDYE4 →	+0.082	+3.333	.005	<.001	3	2
LARGE_INTESTINE	DPH5 →	+0.538	+3.212	.007	.006	3	2
LARGE_INTESTINE	ATG4C →	+0.601	+3.212	.001	.006	3	2
STOMACH	GRM6 →	+0.024	+3.209	<.001	.007	3	1
STOMACH	SNTG2 →	+0.374	+4.366	<.001	<.001	3	1
STOMACH	HBG1 →	+0.226	+3.700	<.001	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 277 associations by consensus.

SPDYE4 by PYGB expression — BLOOD_Leukemia

Explore this box plot interactively →