PYCR3

Across TCGA patient cohorts, PYCR3 mutation is significantly associated with the RNA expression of many other genes, with 132 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PYCR3-associated genes across cancer lineages are RNA5SP205, RPEP5, and MIR5591. Each is linked with PYCR3 in more than 1 cancer types. Because this analysis shows association rather than direction, both PYCR3-to-partner and partner-to-PYCR3 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RNA5SP205 grouped by PYCR3-low versus PYCR3-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PYCR3→partner) and Y-score (partner→PYCR3) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	RNA5SP205 →	+0.420	+4.045	<.001	<.001	3	2
BLCA	RPEP5 →	+0.139	+7.640	<.001	.009	3	2
BLCA	MIR5591 →	+0.942	+7.640	<.001	.009	3	2
UCEC	RNVU1-28 →	+1.136	+2.442	<.001	.005	3	1
BLCA	DEFB107B →	+0.099	+7.640	<.001	.009	3	1
BLCA	RNA5SP524 →	+0.293	+7.640	<.001	.009	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 132 associations by consensus.

RNA5SP205 by PYCR3 expression — UCEC

Explore this box plot interactively →