PYCR3

Across TCGA pan-cancer cohorts, PYCR3 RNA differs between tumor and matched normal tissue in 17 of 18 cancer types tested, making tumor–normal expression one of PYCR3’s most consistent transcriptional readouts.

The strongest signal is observed in colon adenocarcinoma (COAD), where PYCR3 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PYCR3 is over-expressed in tumor, although a few such as THCA and KICH show the opposite, repressed pattern.

COAD, HNSC, and BLCA are the cancer types where PYCR3 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PYCR3 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
COAD	Female	III,IV	+2.360	<.001	11	view →
HNSC	Male	IV	+1.361	<.001	10	view →
BLCA	Male	All	+1.180	<.001	10	view →
STAD	Male	III,IV	+1.819	<.001	9	view →
LIHC	Male	All	+1.758	<.001	9	view →
LUAD	Female	III,IV	+1.437	<.001	9	view →
LUSC	Female	II,III,IV	+1.625	<.001	8	view →
KIRP	Male	II,III,IV	+0.631	<.001	8	view →
THCA	Male	III,IV	−0.647	<.001	7	view →
BRCA	All	III,IV	+1.489	<.001	6	view →
KICH	Female	II,III,IV	−1.195	<.001	6	view →
UCEC	All	All	+1.039	<.001	6	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 17 lineages.

PYCR3–COAD

Open the COAD breakdown →