PYCARD-AS1

Across TCGA patient cohorts, PYCARD-AS1 RNA expression is significantly associated with the go_rna of many other GO terms, with 6,895 significant associations in total. LGG shows the largest number of these associations.

The most reproducible PYCARD-AS1-associated GO terms across cancer lineages are Regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II, Positive regulation of T-helper 17 type immune response, and Positive regulation of CD4-positive, alpha-beta T cell activation. Each is linked with PYCARD-AS1 in more than 17 cancer types. Because this analysis shows association rather than direction, both PYCARD-AS1-to-partner and partner-to-PYCARD-AS1 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, Regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II grouped by PYCARD-AS1-low versus PYCARD-AS1-high in GBM.

RNA expression associated GO terms by consensus

Ranked by combined sampling and lineage consensus. X-score (PYCARD-AS1→partner) and Y-score (partner→PYCARD-AS1) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner GO term	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
GBM	Regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II →	+0.073	+0.191	.001	<.001	3	17
KICH	Positive regulation of T-helper 17 type immune response →	+0.041	+0.079	.001	.001	2	18
KICH	Positive regulation of CD4-positive, alpha-beta T cell activation →	+0.043	+0.141	<.001	<.001	3	16
LIHC	Regulation of antigen processing and presentation of peptide antigen →	+0.057	+0.136	<.001	<.001	3	16
KICH	Positive regulation of monocyte differentiation →	+0.056	+0.099	<.001	.001	3	16
SARC	Osmosensory signaling pathway →	+0.054	+0.130	<.001	<.001	3	16

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,895 associations by consensus.

Regulation of antigen processing and presentation of peptide or polysaccharide antigen via MHC class II by PYCARD-AS1 expression — GBM

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