PYCARD-AS1

Across TCGA pan-cancer cohorts, PYCARD-AS1 RNA is linked to patient survival in 18 of 34 cancer types, making it the most broadly survival-associated PYCARD-AS1 data layer.

The strongest signal is observed in kidney renal clear cell carcinoma (KIRC), where higher PYCARD-AS1 RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PYCARD-AS1 expression acts as an unfavorable survival marker, although some lineages such as SKCM and UVM show a favorable association.

KIRC, LGG, and DLBC are the cancer types where PYCARD-AS1 RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
KIRC	OS	Median	All	0.563	0.688	<.001	124	view →
LGG	DFS	Tertile	All	0.313	0.530	<.001	30	view →
DLBC	DFS	Median	III,IV	0.140	0.917	.010	22	view →
ACC	OS	Quartile	II,III,IV	0.185	0.555	.004	22	view →
LIHC	OS	Tertile	III,IV	0.209	0.604	.004	21	view →
READ	DFS	Tertile	All	0.728	0.891	.007	19	view →
SKCM	DFS	Median	IV	0.672	0.192	.008	14	view →
HNSC	OS	Median	III,IV	0.558	0.685	.004	14	view →
THCA	DFS	Median	III,IV	0.856	0.927	.019	12	view →
OV	OS	Tertile	IV	0.233	0.505	.008	10	view →
COAD	OS	Tertile	IV	0.291	0.613	.019	10	view →
UVM	DFS	Quartile	III,IV	0.900	0.470	.014	5	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 18 lineages.

PYCARD-AS1–KIRC (OS)

Open the KIRC breakdown →