PYCARD-AS1

Across TCGA pan-cancer cohorts, PYCARD-AS1 RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PYCARD-AS1’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PYCARD-AS1 RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PYCARD-AS1 is over-expressed in tumor, although a few such as KICH and LUAD show the opposite, repressed pattern.

HNSC, KIRC, and BRCA are the cancer types where PYCARD-AS1 tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PYCARD-AS1 RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	All	III,IV	+0.251	<.001	11	view →
KIRC	All	III,IV	+0.146	<.001	9	view →
BRCA	All	III,IV	+0.281	<.001	8	view →
COAD	All	All	+0.255	<.001	7	view →
LIHC	All	All	+0.106	<.001	5	view →
KICH	All	II,III,IV	−0.097	.007	5	view →
STAD	All	All	+0.225	.002	4	view →
CHOL	All	All	+0.424	<.001	3	view →
THCA	All	III,IV	+0.095	.011	3	view →
KIRP	All	All	+0.060	.042	3	view →
LUAD	Male	III,IV	−0.261	.022	2	view →
PRAD	All	All	−0.083	<.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PYCARD-AS1–HNSC

Open the HNSC breakdown →