PXN

Across TCGA cell cohorts, PXN mutation is significantly associated with the drug of many other genes, with 21 significant associations in total. LARGE_INTESTINE shows the largest number of these associations.

The most reproducible PXN-associated genes across cancer lineages are AZD5582, Selumetinib, and Dacarbazine. Each is linked with PXN in more than 1 cancer types. Because this analysis shows association rather than direction, both PXN-to-partner and partner-to-PXN results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, AZD5582 grouped by PXN-low versus PXN-high in LARGE_INTESTINE.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PXN→partner) and Y-score (partner→PXN) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
LARGE_INTESTINE	AZD5582 →	+0.658	+2.868	.017	.022	3	1
LARGE_INTESTINE	Selumetinib →	-0.548	-2.743	.049	.046	3	1
LARGE_INTESTINE	Dacarbazine →	+0.352	+3.000	.006	.017	3	1
LARGE_INTESTINE	50869 →	+0.446	+2.871	.025	.021	3	1
LARGE_INTESTINE	CAY10603 →	+0.428	+2.874	.047	.021	3	1
LARGE_INTESTINE	WYE-125132 →	+0.502	+2.874	.039	.021	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 21 associations by consensus.

AZD5582 by PXN expression — LARGE_INTESTINE

Explore this box plot interactively →