PXN

Across TCGA pan-cancer cohorts, PXN RNA is linked to patient survival in 26 of 34 cancer types, making it the most broadly survival-associated PXN data layer compared with 4 for mutation status and 6 for mass-spec protein.

The strongest signal is observed in mesothelioma (MESO), where higher PXN RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PXN expression acts as an unfavorable survival marker, although some lineages such as UCS and SCLC show a favorable association.

MESO, HNSC, and LUSC are the cancer types where PXN RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
MESO	OS	Median	All	0.267	0.501	<.001	129	view →
HNSC	OS	Median	All	0.703	0.796	.001	66	view →
LUSC	DFS	Median	All	0.706	0.807	<.001	63	view →
UCS	DFS	Median	II,III,IV	0.591	0.300	.017	56	view →
LGG	DFS	Median	All	0.653	0.828	<.001	54	view →
LIHC	DFS	Median	All	0.461	0.618	<.001	51	view →
GBM	OS	Quartile	All	0.322	0.502	.003	33	view →
LUAD	DFS	Tertile	All	0.589	0.735	.003	33	view →
OV	OS	Median	All	0.271	0.370	.008	30	view →
SCLC	DFS	Median	All	0.990	0.538	.004	28	view →
PAAD	OS	Median	All	0.327	0.632	.001	27	view →
CESC	DFS	Median	All	0.644	0.832	<.001	26	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 26 lineages.

PXN–MESO (OS)

Open the MESO breakdown →