PXN

Across TCGA pan-cancer cohorts, PXN RNA differs between tumor and matched normal tissue in 13 of 18 cancer types tested, making tumor–normal expression one of PXN’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PXN RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PXN is over-expressed in tumor, although a few such as UCEC and BRCA show the opposite, repressed pattern.

HNSC, LIHC, and UCEC are the cancer types where PXN tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PXN RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.940	<.001	12	view →
LIHC	Female	II,III,IV	+1.199	<.001	9	view →
UCEC	All	All	−0.938	<.001	6	view →
STAD	All	II,III,IV	+0.870	.004	6	view →
BRCA	Female	All	−0.467	<.001	4	view →
KIRC	All	All	+0.258	.003	4	view →
CHOL	Male	All	+2.265	<.001	3	view →
LUSC	Female	All	−0.583	.007	3	view →
ESCA	All	All	+0.957	.008	2	view →
LUAD	Female	All	−0.472	<.001	2	view →
PRAD	All	All	+0.414	<.001	2	view →
COAD	Female	All	−0.292	.002	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 13 lineages.

PXN–HNSC

Open the HNSC breakdown →