PXDNL

Across TCGA patient cohorts, PXDNL protein abundance is significantly associated with the protein abundance of many other proteins, with 376 significant associations in total. GBM shows the largest number of these associations.

The most reproducible PXDNL-associated proteins across cancer lineages are IL6ST_S667, TMEM102, and TPRN_S241. Each is linked with PXDNL in more than 1 cancer types. Because this analysis shows association rather than direction, both PXDNL-to-partner and partner-to-PXDNL results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PXDNL versus IL6ST_S667 in BRCA, with a Pearson correlation of 0.70.

protein abundance associated proteins by consensus

Ranked by combined sampling and lineage consensus. X-score (PXDNL→partner) and Y-score (partner→PXDNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner protein	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	IL6ST_S667 →	+0.952	+1.415	.001	.006	3	1
BRCA	TMEM102 →	+0.652	+2.352	.001	.006	3	1
BRCA	TPRN_S241 →	+0.965	+1.474	<.001	.003	3	1
BRCA	ZMYM4_S1181 →	+0.941	+1.490	<.001	.003	3	1
GBM	GYPA_S139 →	+0.707	+0.570	<.001	<.001	3	1
GBM	HDAC7_S181 →	+0.455	+0.484	.002	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 376 associations by consensus.

PXDNL vs IL6ST_S667 — BRCA

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