PXDNL

Across TCGA pan-cancer cohorts, PXDNL RNA is linked to patient survival in 25 of 34 cancer types, making it the most broadly survival-associated PXDNL data layer compared with 8 for mutation status.

The strongest signal is observed in bladder urothelial carcinoma (BLCA), where higher PXDNL RNA is associated with worse overall survival. In most high-consensus cancer types, elevated PXDNL expression acts as an unfavorable survival marker, although some lineages such as CHOL and DLBC show a favorable association.

BLCA, UVM, and BRCA are the cancer types where PXDNL RNA most reproducibly stratifies survival.

RNA survival associations by lineage

Ranked by sampling consensus. AUC1 and AUC2 indicate survival in the high- and low-expression groups, respectively; the lower AUC marks the poorer-surviving group. p-values are from the log-rank test.

Lineage	Measure	Split	Stage	AUC1 high	AUC2 low	p	Sampling consensus
BLCA	OS	Quartile	II,III,IV	0.268	0.546	<.001	111	view →
UVM	DFS	Median	All	0.569	0.894	<.001	100	view →
BRCA	OS	Median	All	0.527	0.627	<.001	66	view →
LGG	OS	Median	All	0.737	0.882	<.001	54	view →
CESC	OS	Quartile	All	0.407	0.783	<.001	52	view →
COAD	DFS	Median	All	0.623	0.745	.008	33	view →
KIRP	DFS	Quartile	All	0.738	0.927	<.001	32	view →
CHOL	DFS	Median	II,III,IV	0.690	0.151	.004	29	view →
UCEC	DFS	Tertile	All	0.792	0.901	<.001	26	view →
STAD	DFS	Tertile	IV	0.088	0.419	.016	22	view →
DLBC	DFS	Tertile	All	0.939	0.554	.010	20	view →
TGCT	DFS	Quartile	All	0.852	0.561	.003	16	view →

Pink = unfavorable, green = favorable. Showing the 12 strongest of 25 lineages.

PXDNL–BLCA (OS)

Open the BLCA breakdown →