PXDNL

Across TCGA patient cohorts, PXDNL mutation is significantly associated with the RNA expression of many other genes, with 6,957 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PXDNL-associated genes across cancer lineages are RAC3, AUNIP, and NUSAP1. Each is linked with PXDNL in more than 7 cancer types. Because this analysis shows association rather than direction, both PXDNL-to-partner and partner-to-PXDNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, RAC3 grouped by PXDNL-low versus PXDNL-high in STAD.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PXDNL→partner) and Y-score (partner→PXDNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
STAD	RAC3 →	+0.969	+3.601	<.001	.001	3	8
UCEC	AUNIP →	+0.435	+1.477	<.001	<.001	3	6
STAD	NUSAP1 →	+0.535	+3.334	.007	.005	3	6
UCEC	CHAF1B →	+0.401	+1.306	<.001	<.001	3	6
UCEC	TIMM21 →	+0.380	+1.537	<.001	<.001	3	6
HNSC	PSMG1 →	+0.400	+3.619	.003	.001	3	6

Each partner links to its Q-omics profile. Showing the 6 strongest of 6,957 associations by consensus.

RAC3 by PXDNL expression — STAD

Explore this box plot interactively →