PXDNL

Across TCGA cell cohorts, PXDNL mutation is significantly associated with the RNA expression of many other genes, with 1,065 significant associations in total. BLOOD_Leukemia shows the largest number of these associations.

The most reproducible PXDNL-associated genes across cancer lineages are CENPV, GLB1L3, and TTC33. Each is linked with PXDNL in more than 2 cancer types. Because this analysis shows association rather than direction, both PXDNL-to-partner and partner-to-PXDNL results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, CENPV grouped by PXDNL-low versus PXDNL-high in SKIN.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PXDNL→partner) and Y-score (partner→PXDNL) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
SKIN	CENPV →	+1.225	+2.459	.001	.006	3	3
BLOOD_Leukemia	GLB1L3 →	+1.366	+3.369	<.001	.006	3	3
SKIN	TTC33 →	+0.420	+1.808	.005	.001	3	3
SKIN	ARPP19 →	+0.358	+1.458	.007	.009	3	3
SKIN	C12orf65 →	+0.299	+3.087	.004	.006	3	3
SKIN	TXNL4B →	+0.507	+3.087	<.001	.006	3	3

Each partner links to its Q-omics profile. Showing the 6 strongest of 1,065 associations by consensus.

CENPV by PXDNL expression — SKIN

Explore this box plot interactively →