PWAR6

Across TCGA patient cohorts, PWAR6 mutation is significantly associated with the RNA expression of many other genes, with 23 significant associations in total. UCEC shows the largest number of these associations.

The most reproducible PWAR6-associated genes across cancer lineages are MIR449A, RNU1-17P, and MIR215. Each is linked with PWAR6 in more than 1 cancer types. Because this analysis shows association rather than direction, both PWAR6-to-partner and partner-to-PWAR6 results are reported.

Each partner links to its own Q-omics profile. The box plot shows the strongest example, MIR449A grouped by PWAR6-low versus PWAR6-high in UCEC.

mutation associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PWAR6→partner) and Y-score (partner→PWAR6) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
UCEC	MIR449A →	+0.258	+4.260	<.001	.007	3	1
UCEC	RNU1-17P →	+0.275	+3.520	.003	.006	3	1
UCEC	MIR215 →	+0.652	+3.169	.006	.006	3	1
UCEC	MT-TA →	+0.363	+4.069	<.001	.002	3	1
UCEC	RNA5SP35 →	+0.302	+3.474	.004	.006	3	1
UCEC	RNU6-130P →	+0.745	+3.452	.004	.003	3	1

Each partner links to its Q-omics profile. Showing the 6 strongest of 23 associations by consensus.

MIR449A by PWAR6 expression — UCEC

Explore this box plot interactively →