PVR

Across TCGA patient cohorts, PVR protein abundance is significantly associated with the RNA expression of many other genes, with 9,254 significant associations in total. LUAD shows the largest number of these associations.

The most reproducible PVR-associated genes across cancer lineages are BCL2, SEC61G, and CHRDL1. Each is linked with PVR in more than 5 cancer types. Because this analysis shows association rather than direction, both PVR-to-partner and partner-to-PVR results are reported.

Each partner links to its own Q-omics profile. The scatter plot shows the strongest example, PVR versus BCL2 in BRCA, with a Pearson correlation of -0.36.

protein abundance associated genes by consensus

Ranked by combined sampling and lineage consensus. X-score (PVR→partner) and Y-score (partner→PVR) are standardized regression coefficients; both directions are reported because the association is undirected. p-values are from the association test.

Lineage	Partner gene	X-score	Y-score	p(X)	p(Y)	Sampling consensus	Lineage consensus
BRCA	BCL2 →	-0.770	-0.361	.002	.001	3	6
HNSC	SEC61G →	+0.920	+0.343	.002	<.001	3	5
UCEC	CHRDL1 →	-1.728	-0.505	<.001	<.001	3	4
GBM	DMAC2 →	+0.428	+0.383	<.001	<.001	3	4
LUAD	TNFSF8 →	-0.605	-0.434	<.001	<.001	3	4
HNSC	FAM117A →	-0.701	-0.285	<.001	.006	3	4

Each partner links to its Q-omics profile. Showing the 6 strongest of 9,254 associations by consensus.

PVR vs BCL2 — BRCA

Explore this scatter interactively →