PVR

Across TCGA pan-cancer cohorts, PVR RNA differs between tumor and matched normal tissue in 14 of 18 cancer types tested, making tumor–normal expression one of PVR’s most consistent transcriptional readouts.

The strongest signal is observed in head and neck squamous cell carcinoma (HNSC), where PVR RNA is more highly expressed in tumor relative to normal tissue. In most cancer types PVR is over-expressed in tumor, although a few such as THCA and LUSC show the opposite, repressed pattern.

HNSC, COAD, and KIRP are the cancer types where PVR tumor–normal differential expression is most reproducible.

RNA tumor vs normal associations by lineage

Ranked by sampling consensus. Fold-change is the tumor-versus-normal difference in PVR RNA (log₂); positive values indicate higher expression in tumor. p-values are from the differential-expression test.

Lineage	Gender	Stage	Fold-change	p	Sampling consensus
HNSC	Female	III,IV	+1.661	<.001	12	view →
COAD	Male	IV	+1.362	<.001	12	view →
KIRP	All	III,IV	+1.350	.001	9	view →
STAD	Male	III,IV	+1.736	<.001	8	view →
LIHC	Female	II,III,IV	+1.092	<.001	8	view →
KIRC	Male	All	+0.418	<.001	8	view →
BLCA	Male	IV	+1.207	<.001	7	view →
UCEC	All	III,IV	+1.031	.004	6	view →
THCA	Female	All	−0.389	<.001	6	view →
ESCA	All	All	+1.354	<.001	3	view →
READ	All	All	+0.961	<.001	3	view →
CHOL	Male	All	+0.995	.001	2	view →

Pink = over-expressed in tumor, green = repressed in tumor. Showing the 12 strongest of 14 lineages.

PVR–HNSC

Open the HNSC breakdown →